Slide 1:
Hed: Treating Major Hyperoxaluria
Dek: This uncommon dysfunction causes kidney stones and probably kidney harm. Discover out extra about your therapy choices.
Slide 2:
Major hyperoxaluria is a uncommon genetic dysfunction the place your physique creates an excessive amount of of a substance referred to as oxalate.
When an excessive amount of oxalate builds up within the kidneys and combines with calcium, it varieties kidney stones and may result in kidney failure.
Slide 3:
There are three kinds of PH:
PH1
PH2
PH3
Therapy choices rely on which kind of PH you have got, however the therapy aim for all types of PH is to stop oxalate from build up within the kidneys and different components of your physique.
Slide 4:
Some therapy choices embrace:
Vitamin B6 (pyridoxine)
When taken at excessive doses, vitamin B6 may also help decrease oxalate ranges. This therapy works for about 3 out of 10 folks. It is just helpful for sufferers with PH1.
Slide 5:
Prescription Medicines
Lumasiran and nedosiran may be given as injections underneath the pores and skin to decrease oxalate ranges. These drugs are solely helpful for sufferers with PH1.
Slide 6:
Consuming Loads of Fluids
Consuming plenty of fluid (particularly water) every day may also help flush the oxalate out of your physique.
Slide 7:
Citrate or Bicarbonate Salts
An excessive amount of acid in your urine will increase the chance of kidney stones. Consuming citrate and bicarbonate salt like:
Potassium citrate
Potassium bicarbonate
Sodium citrate
Sodium bicarbonate
can decrease the acidity of your urine.
Slide 8:
Avoiding Excessive Ranges of Vitamin C
An excessive amount of vitamin C in your weight loss plan — from meals or dietary supplements — can increase oxalate.
Slide 9:
Avoiding Meals Excessive in Oxalate
Excessive-oxalate meals embrace:
Nuts
Chocolate
Candy potatoes
Plums
Beets
Rhubarb
Spinach
Tofu
Strawberries
In the event you select to eat these meals, eat calcium-rich meals as effectively to assist stop the oxalate from reaching your kidneys and creating kidney stones.
Slide 10:
How effectively main hyperoxaluria remedies work is dependent upon your total well being and the way extreme your situation is.
Discuss to your healthcare supplier about what may give you the results you want.
This academic useful resource was created with assist from Alnylam.
